Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a single irreparable DSB is sufficient to activate the DDC and induce cell cycle arrest prior to anaphase for about 12–15 hr, after w...

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Bibliographic Details
Main Authors: Felix Y Zhou, David P Waterman, Marissa Ashton, Suhaily Caban-Penix, Gonen Memisoglu, Vinay V Eapen, James E Haber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
double-strand break
DSB
DNA damage checkpoint
DDC
spindle assembly 3 checkpoint
SAC
Online Access:https://elifesciences.org/articles/94334
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https://elifesciences.org/articles/94334

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