CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.

CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.

RNA-binding proteins have emerged as causal agents of complex neurological diseases. Mice deficient for neuronal RNA-binding protein CELF4 have a complex neurological disorder with epilepsy as a prominent feature. Human CELF4 has recently been associated with clinical features similar to those seen...

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Main Authors: Jacy L Wagnon, Michael Briese, Wenzhi Sun, Connie L Mahaffey, Tomaž Curk, Gregor Rot, Jernej Ule, Wayne N Frankel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003067&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003067&type=printable

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