Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants
Multiple myeloma (MM) is a malignant plasma cell disorder and more than 30% of patients with this pathology develop osteolytic lesions in the jaw. Either pamidronate or zoledronic acid is recommended in patients with MM who have one or more lytic lesions. However, bisphosphonate-related osteonecrosi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2011/568246 |
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| _version_ | 1832553981016014848 |
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| author | Luis Junquera Lorena Gallego Alejandro Pelaz |
| author_facet | Luis Junquera Lorena Gallego Alejandro Pelaz |
| author_sort | Luis Junquera |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a malignant plasma cell disorder and more than 30% of patients with this pathology develop osteolytic lesions in the jaw. Either pamidronate or zoledronic acid is recommended in patients with MM who have one or more lytic lesions. However, bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been described as a complication associated with their use. Otherwise, the use of endosseous implants in oral rehabilitation is a well-established procedure, with good long-term success although systemic factors may affect the bone healing around dental implants. We report the first case reported of MM adjacent to a mandibular dental implant in a patient who developed BRONJ in the same area after intravenous zoledronate treatment. We discuss possible pathogeny of this particular and interesting phenomena. |
| format | Article |
| id | doaj-art-e9be0aa10a38452aaebe0ad99bd8c1db |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-e9be0aa10a38452aaebe0ad99bd8c1db2025-02-03T05:52:50ZengWileyCase Reports in Dentistry2090-64472090-64552011-01-01201110.1155/2011/568246568246Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental ImplantsLuis Junquera0Lorena Gallego1Alejandro Pelaz2Oral and Maxillofacial Surgery, Dental School, University of Oviedo, Catedrático José Serrano Street, 33009 Oviedo, SpainDepartment of Oral and Maxillofacial Surgery, Cabueñes Hospital, 33394 Gijón, SpainDepartment of Oral and Maxillofacial Surgery, Central University Hospital, 33006 Oviedo, SpainMultiple myeloma (MM) is a malignant plasma cell disorder and more than 30% of patients with this pathology develop osteolytic lesions in the jaw. Either pamidronate or zoledronic acid is recommended in patients with MM who have one or more lytic lesions. However, bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been described as a complication associated with their use. Otherwise, the use of endosseous implants in oral rehabilitation is a well-established procedure, with good long-term success although systemic factors may affect the bone healing around dental implants. We report the first case reported of MM adjacent to a mandibular dental implant in a patient who developed BRONJ in the same area after intravenous zoledronate treatment. We discuss possible pathogeny of this particular and interesting phenomena.http://dx.doi.org/10.1155/2011/568246 |
| spellingShingle | Luis Junquera Lorena Gallego Alejandro Pelaz Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants Case Reports in Dentistry |
| title | Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants |
| title_full | Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants |
| title_fullStr | Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants |
| title_full_unstemmed | Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants |
| title_short | Multiple Myeloma and Bisphosphonate-Related Osteonecrosis of the Mandible Associated with Dental Implants |
| title_sort | multiple myeloma and bisphosphonate related osteonecrosis of the mandible associated with dental implants |
| url | http://dx.doi.org/10.1155/2011/568246 |
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