Development and validation of a multimodal model integrating gut microbiota and metabolite for identifying sarcopenia in patients with MASLD: a study from two centers in China

Development and validation of a multimodal model integrating gut microbiota and metabolite for identifying sarcopenia in patients with MASLD: a study from two centers in China

Abstract Background and aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disease worldwide, and identifying sarcopenia is critical since it is correlated with poor prognosis. Little is known about mechanistic alterations in the pathogenesis of this cond...

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Bibliographic Details
Main Authors: Sizhe Wan, Mingkai Li, Wanjun Li, Yuexiang Ren, Yuankai Wu, Qingtian Luo, Wei Gong
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Nutrition Journal
Subjects:
Metabolic dysfunction-associated steatotic liver disease
Sarcopenia
Gut microbiota
Metabolite
Shotgun metagenomic sequencing
Untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics
Online Access:https://doi.org/10.1186/s12937-025-01198-2
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https://doi.org/10.1186/s12937-025-01198-2

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