Aberrant anabolism hinders constructive metabolism of chondrocytes by pharmacotherapy in osteoarthritis

Aberrant anabolism hinders constructive metabolism of chondrocytes by pharmacotherapy in osteoarthritis

Osteoarthritis (OA) is a highly prevalent and disabling disease with an unmet therapeutic need. The characteristic cartilage loss and alteration of other joint structures result from a complex interaction of multiple risk factors, with mechanical overload consistently playing a central role. This ov...

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Bibliographic Details
Main Authors:	Raquel Largo, Aranzazu Mediero, Cristina Villa-Gomez, Ismael Bermejo-Alvarez, Gabriel Herrero-Beaumont
Format:	Article
Language:	English
Published:	The British Editorial Society of Bone & Joint Surgery 2025-03-01
Series:	Bone & Joint Research
Subjects:	osteoarthritis mechanical overloading inflammation aberrant anabolism treatment osteoarthritis (oa) chondrocytes cartilage tissue osteoarthritic chondrocytes obesity pharmacotherapy articular cartilage mechanical stress overweight metabolic syndrome
Online Access:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.143.BJR-2024-0241.R1
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