Aberrant anabolism hinders constructive metabolism of chondrocytes by pharmacotherapy in osteoarthritis

Aberrant anabolism hinders constructive metabolism of chondrocytes by pharmacotherapy in osteoarthritis

Osteoarthritis (OA) is a highly prevalent and disabling disease with an unmet therapeutic need. The characteristic cartilage loss and alteration of other joint structures result from a complex interaction of multiple risk factors, with mechanical overload consistently playing a central role. This ov...

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Bibliographic Details
Main Authors: Raquel Largo, Aranzazu Mediero, Cristina Villa-Gomez, Ismael Bermejo-Alvarez, Gabriel Herrero-Beaumont
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-03-01
Series:Bone & Joint Research
Subjects:
osteoarthritis
mechanical overloading
inflammation
aberrant anabolism
treatment
osteoarthritis (oa)
chondrocytes
cartilage tissue
osteoarthritic chondrocytes
obesity
pharmacotherapy
articular cartilage
mechanical stress
overweight
metabolic syndrome
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.143.BJR-2024-0241.R1
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https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.143.BJR-2024-0241.R1

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