The posttraumatic response of CD4+ regulatory T cells is modulated by direct cell-cell contact via CD40L- and P-selectin-dependent pathways

The posttraumatic response of CD4+ regulatory T cells is modulated by direct cell-cell contact via CD40L- and P-selectin-dependent pathways

CD4+ FoxP3+ regulatory T cells (CD4+ Tregs) are important for the posttraumatic anti-inflammatory host response. As described previously, platelets are able to modulate CD4+ Treg activity in a reciprocally activating interaction following injury. The underlying mechanisms of the posttraumatic intera...

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Bibliographic Details
Main Authors: Marco-Christopher Rupp, Christian Benjamin Bergmann, Sonja Jung, Matthias Bock, Peter Biberthaler, Laura Heimann, Marc Hanschen
Format: Article
Language:English
Published: Termedia Publishing House 2021-10-01
Series:Central European Journal of Immunology
Subjects:
cd4+ regulatory t cells
platelets
trauma
adaptive immune response
hemostasis
cell communication.
Online Access:https://www.termedia.pl/The-posttraumatic-response-of-CD4-regulatory-T-cells-is-modulated-by-direct-cell-cell-contact-via-CD40L-and-P-selectin-dependent-pathways,10,45167,1,1.html
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https://www.termedia.pl/The-posttraumatic-response-of-CD4-regulatory-T-cells-is-modulated-by-direct-cell-cell-contact-via-CD40L-and-P-selectin-dependent-pathways,10,45167,1,1.html

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