A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

Abstract Actin cytoskeleton dynamics is essential for proper nervous system development and function. A conserved set of neuronal-specific microexons influences multiple aspects of neurobiology; however, their roles in regulating the actin cytoskeleton are unknown. Here, we study a microexon in DAAM...

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Main Authors: Patryk Poliński, Marta Miret Cuesta, Alfonsa Zamora-Moratalla, Federica Mantica, Gerard Cantero-Recasens, Carlotta Viana, Miguel Sabariego-Navarro, Davide Normanno, Luis P. Iñiguez, Cruz Morenilla-Palao, Patricia Ordoño, Sophie Bonnal, Jonathan D. Ellis, Raúl Gómez-Riera, Hugo Fanlo-Ucar, Dominic S. Yap, María Martínez De Lagrán, Álvaro Fernández-Blanco, Cristina Rodríguez-Marin, Jon Permanyer, Orsolya Fölsz, Eduardo Dominguez-Sala, Cesar Sierra, Diana Legutko, José Wojnacki, Juan Luis Musoles Lleo, Maria Pia Cosma, Francisco José Muñoz, Benjamin J. Blencowe, Eloisa Herrera, Mara Dierssen, Manuel Irimia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59430-w
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https://doi.org/10.1038/s41467-025-59430-w

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