Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research
Summary: Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chronic fatigue and sleep disturbances in Long COVID are intricately linked to disruptions in cir...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | EClinicalMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537025000057 |
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| author | Achilleas Livieratos Steven W. Lockley Sotirios Tsiodras |
| author_facet | Achilleas Livieratos Steven W. Lockley Sotirios Tsiodras |
| author_sort | Achilleas Livieratos |
| collection | DOAJ |
| description | Summary: Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chronic fatigue and sleep disturbances in Long COVID are intricately linked to disruptions in circadian rhythms, driven by distinct molecular and cellular mechanisms triggered by SARS-CoV-2 infection. This can be driven by various mechanisms including dysregulation of key clock genes (CLOCK, BMAL1, PER2), mitochondrial dysfunction impairing oxidative phosphorylation, and cytokine-induced neuroinflammation (e.g., interleukin-6, tumor necrosis factor-alpha). Epigenetic changes, including DNA methylation at clock-related loci, particularly in peripheral tissues, further contribute to systemic circadian dysregulation. This work underscores the multifaceted molecular and systemic disruptions to circadian regulation in relation to fatigue and sleep disturbances identified as post-infectious sequelae, focusing on the Long COVID condition. |
| format | Article |
| id | doaj-art-e97081825e074a159500ee60a8f8b1b0 |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-e97081825e074a159500ee60a8f8b1b02025-01-19T06:26:32ZengElsevierEClinicalMedicine2589-53702025-02-0180103073Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further researchAchilleas Livieratos0Steven W. Lockley1 Sotirios Tsiodras2Independent Researcher, Athens 152 38, Greece; Corresponding author.Surrey Sleep Research Centre, School of Biosciences, University of Surrey, Surrey, GU2 7YW, UK4th Department of Internal Medicine, Attikon University Hospital, Athens 124 62, GreeceSummary: Chronic fatigue syndrome (CFS) remains a subject of scientific research specifically with regards to its association with infections, including the more recently described Long COVID condition. Chronic fatigue and sleep disturbances in Long COVID are intricately linked to disruptions in circadian rhythms, driven by distinct molecular and cellular mechanisms triggered by SARS-CoV-2 infection. This can be driven by various mechanisms including dysregulation of key clock genes (CLOCK, BMAL1, PER2), mitochondrial dysfunction impairing oxidative phosphorylation, and cytokine-induced neuroinflammation (e.g., interleukin-6, tumor necrosis factor-alpha). Epigenetic changes, including DNA methylation at clock-related loci, particularly in peripheral tissues, further contribute to systemic circadian dysregulation. This work underscores the multifaceted molecular and systemic disruptions to circadian regulation in relation to fatigue and sleep disturbances identified as post-infectious sequelae, focusing on the Long COVID condition.http://www.sciencedirect.com/science/article/pii/S2589537025000057Long COVIDPost-infectious fatigueCircadian rhythmsChronic fatigue syndrome |
| spellingShingle | Achilleas Livieratos Steven W. Lockley Sotirios Tsiodras Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research EClinicalMedicine Long COVID Post-infectious fatigue Circadian rhythms Chronic fatigue syndrome |
| title | Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research |
| title_full | Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research |
| title_fullStr | Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research |
| title_full_unstemmed | Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research |
| title_short | Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research |
| title_sort | post infectious fatigue and circadian rhythm disruption in long covid and other infections a need for further research |
| topic | Long COVID Post-infectious fatigue Circadian rhythms Chronic fatigue syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2589537025000057 |
| work_keys_str_mv | AT achilleaslivieratos postinfectiousfatigueandcircadianrhythmdisruptioninlongcovidandotherinfectionsaneedforfurtherresearch AT stevenwlockley postinfectiousfatigueandcircadianrhythmdisruptioninlongcovidandotherinfectionsaneedforfurtherresearch AT sotiriostsiodras postinfectiousfatigueandcircadianrhythmdisruptioninlongcovidandotherinfectionsaneedforfurtherresearch |