Stress fiber strain is zero in normal aortic smooth muscle, elevated in hypertensive stretch, and minimal in wall thickening rats

Stress fiber strain is zero in normal aortic smooth muscle, elevated in hypertensive stretch, and minimal in wall thickening rats

Abstract Hypertension causes aortic wall thickening until the original wall stress is restored. We hypothesized that this regulation involves stress fiber (SF) tension transmission to the nucleus in smooth muscle cells (SMCs) and investigated the strain in the SF direction as a condition required fo...

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Bibliographic Details
Main Authors: Shukei Sugita, Rintaro Kawai, Yoshihiro Ujihara, Masanori Nakamura
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Hypertension
Fluorescent microscopy
Vascular smooth muscle cells
Stress fiber
Normal strain
Online Access:https://doi.org/10.1038/s41598-024-81229-w
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https://doi.org/10.1038/s41598-024-81229-w

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