A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Abstract Background Uterine fibroids (UFs), benign tumours prevalent in up to 80% of women of reproductive age, are associated with significant morbidity, including abnormal uterine bleeding, pain and infertility. Despite identification of key genomic alterations in MED12 and HMGA2, the pathogenic m...

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Main Authors: Chen-Yi Wang, Martin Philpott, Darragh P O’Brien, Anne Ndungu, Jessica Malzahn, Marina Maritati, Neelam Mehta, Vicki Gamble, Beatriz Martinez-Burgo, Sarah Bonham, Roman Fischer, Kurtis Garbutt, Christian M. Becker, Sanjiv Manek, Adrian L. Harris, Frank Sacher, Maik Obendorf, Nicole Schmidt, Jörg Müller, Thomas M. Zollner, Krina T. Zondervan, Benedikt M. Kessler, Udo Oppermann, Adam P. Cribbs
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-01051-x
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https://doi.org/10.1038/s43856-025-01051-x

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