Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease

Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease

Background The mechanisms underlying the progression of chronic kidney disease (CKD) following acute kidney injury (AKI) remain poorly understood. Senescent cells induce maladaptive repair have been identified as a significant contributor to CKD subsequent to AKI.Purpose The purpose of this study wa...

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Bibliographic Details
Main Authors: Daoqi Shen, Liyu Lin, Yiqi Su, Jiarui Xu, Wuhua Jiang, Zhen Zhang, Yi Fang, Xiaoqiang Ding, Xialian Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Acute kidney injury
AKI-to-CKD transition
cell senescence
fibrosis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2499897
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2499897

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