Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/3200932 |
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| _version_ | 1832565479290437632 |
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| author | Mengjia Gao Jingxin Xin Xiaoling Li Ling Gao Shanshan Shao Meng Zhao |
| author_facet | Mengjia Gao Jingxin Xin Xiaoling Li Ling Gao Shanshan Shao Meng Zhao |
| author_sort | Mengjia Gao |
| collection | DOAJ |
| description | Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA–miRNA–mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out. The present study reveals novel circRNA biomarkers of NASH and reports a potential competing endogenous RNA (ceRNA) regulatory network that might provide insights for further investigation into the underlying pathogenesis of NASH. |
| format | Article |
| id | doaj-art-e90895665eba45d19fdc991fad409306 |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e90895665eba45d19fdc991fad4093062025-02-03T01:07:35ZengWileyGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/3200932Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic SteatohepatitisMengjia Gao0Jingxin Xin1Xiaoling Li2Ling Gao3Shanshan Shao4Meng Zhao5Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyShandong Clinical Research Center of Diabetes and Metabolic DiseasesDepartment of EndocrinologyDepartment of EndocrinologyNonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA–miRNA–mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out. The present study reveals novel circRNA biomarkers of NASH and reports a potential competing endogenous RNA (ceRNA) regulatory network that might provide insights for further investigation into the underlying pathogenesis of NASH.http://dx.doi.org/10.1155/2022/3200932 |
| spellingShingle | Mengjia Gao Jingxin Xin Xiaoling Li Ling Gao Shanshan Shao Meng Zhao Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis Gastroenterology Research and Practice |
| title | Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis |
| title_full | Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis |
| title_fullStr | Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis |
| title_full_unstemmed | Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis |
| title_short | Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis |
| title_sort | differential expression profiles of mrna and noncoding rna and analysis of competitive endogenous rna regulatory networks in nonalcoholic steatohepatitis |
| url | http://dx.doi.org/10.1155/2022/3200932 |
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