Alpha-Lipoic Acid-Mediated Inhibition of LTB4 Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer A549 Cells

Alpha-Lipoic Acid-Mediated Inhibition of LTB4 Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer A549 Cells

Background: Leukotriene B4 (LTB4) plays a crucial role in carcinogenesis by inducing epithelial-mesenchymal transition (EMT), a process associated with tumor progression. The synthesis of LTB4 is mediated by leukotriene A4 hydrolase (LTA4H), and it binds to the receptors BLT1 and BLT2. Dysregulation...

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Main Authors: María José Torres, PhD, Juan Carlos Ríos, PhD, Alexandra Valle, MSc, Sebastián Indo, PhD, Kevin Brockway GV, MSc, Fernanda López-Moncada, PhD, Mario Faúndez, PhD, Enrique A. Castellón, PhD, Héctor R. Contreras, PhD
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Therapeutic Research
Subjects:
Small cell lung carcinoma and non-small cell lung cancer (NSCLC)
Leukotriene A4 Hydrolase (LTA4H)
Leukotriene B4 (LTB4)
Alpha lipoic acid (ALA)
Epithelial Mesenchymal Transition (EMT) and Functional and tumor capacities
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X24000353
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