Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses

Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses

Disrupted in schizophrenia 1 (DISC1) is a pleiotropic scaffold protein that is postulated to comprise large disordered regions and four distinct structured segments with a high proportion of helical or coiled-coil fold. DISC1 associates with over 300 proteins and is associated with several physiolog...

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Bibliographic Details
Main Authors: Abhishek Cukkemane, Nina Becker, Tatsiana Kupreichyk, Henrike Heise, Dieter Willbold, Oliver H. Weiergräber
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Structural Biology: X
Subjects:
Schizophrenia
Disrupted in schizophrenia 1
Aggregation pathway
Proteinopathy
Biophysical analysis
Drug development
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152425000091
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