A single acute alcohol intoxication before fracture insult causes long-term elevated systemic RANKL and OPG levels in young adult mice

A single acute alcohol intoxication before fracture insult causes long-term elevated systemic RANKL and OPG levels in young adult mice

Abstract Binge drinking is the most common form of alcohol abuse and 25–40% of orthopedic trauma patients are intoxicated upon admission. While alcohol consumption prolongs the healing time of bone fractures, the underlying mechanisms by which alcohol leads to this fracture healing disorder remain u...

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Bibliographic Details
Main Authors: Katrin Bundkirchen, Weikang Ye, Tianqi Zhang, Friederike Weidemann, Stefan Lienenklaus, Bastian Welke, Helen Rinderknecht, Borna Relja, Claudia Neunaber
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ethanol
Bone regeneration
Hemorrhagic shock
µCT
Histology
Biomechanics
Online Access:https://doi.org/10.1038/s41598-025-09240-3
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https://doi.org/10.1038/s41598-025-09240-3

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