Synthesis of Temporin-SHa Retro Analogs with Lysine Addition/Substitution and Antibiotic Conjugation to Enhance Antibacterial, Antifungal, and Anticancer Activities

Synthesis of Temporin-SHa Retro Analogs with Lysine Addition/Substitution and Antibiotic Conjugation to Enhance Antibacterial, Antifungal, and Anticancer Activities

In the face of rising the threat of resistant pathogens, antimicrobial peptides (AMPs) offer a viable alternative to the current challenge due to their broad-spectrum activity. This study focuses on enhancing the efficacy of temporin-SHa derived NST-2 peptide (<b>1</b>), which is known f...

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Bibliographic Details
Main Authors: Shahzad Nazir, Arif Iftikhar Khan, Rukesh Maharjan, Sadiq Noor Khan, Muhammad Adnan Akram, Marc Maresca, Farooq-Ahmad Khan, Farzana Shaheen
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antibiotics
Subjects:
temporin-SHa
levofloxacin
antimicrobial peptides
AMPs
antibacterial
antifungal
Online Access:https://www.mdpi.com/2079-6382/13/12/1213
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