Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases
Abstract Parkinson’s disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes. Plasminogen activator inhibitor-1 (SERPIN E1) is known for its association with aging processes and exacerbated α-Synu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00984-3 |
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| author | Milan Zimmermann Madeleine Fandrich Meike Jakobi Benjamin Röben Isabel Wurster Stefanie Lerche Claudia Schulte Shahrzad Zimmermann Christian Deuschle Nicole Schneiderhan-Marra Thomas O. Joos Thomas Gasser Kathrin Brockmann |
| author_facet | Milan Zimmermann Madeleine Fandrich Meike Jakobi Benjamin Röben Isabel Wurster Stefanie Lerche Claudia Schulte Shahrzad Zimmermann Christian Deuschle Nicole Schneiderhan-Marra Thomas O. Joos Thomas Gasser Kathrin Brockmann |
| author_sort | Milan Zimmermann |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes. Plasminogen activator inhibitor-1 (SERPIN E1) is known for its association with aging processes and exacerbated α-Synuclein pathology. We examined whether SERPIN E1 levels in cerebrospinal fluid (CSF) differ among controls (CON, N = 16) and patients with PD (N = 479) or Dementia with Lewy bodies (DLB, N = 67), considering that these conditions represent a spectrum of α-Synuclein pathology. Kaplan-Meier survival analysis stratified by SERPIN E1 tertile levels was conducted to evaluate phenotype-modifying effects. Elevated levels of SERPIN E1 exhibited an association with increased age and lower MOCA scores. Heightened SERPIN E1 levels were observed in individuals diagnosed with DLB, followed by PD and CON, and in males compared to females. The quantification of SERPIN E1 in CSF could potentially serve as a surrogate marker, depicting (pathological) aging processes. |
| format | Article |
| id | doaj-art-e893803e4a874cef8c399872c080aa23 |
| institution | OA Journals |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-e893803e4a874cef8c399872c080aa232025-08-20T02:06:31ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-011111910.1038/s41531-025-00984-3Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseasesMilan Zimmermann0Madeleine Fandrich1Meike Jakobi2Benjamin Röben3Isabel Wurster4Stefanie Lerche5Claudia Schulte6Shahrzad Zimmermann7Christian Deuschle8Nicole Schneiderhan-Marra9Thomas O. Joos10Thomas Gasser11Kathrin Brockmann12Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenNMI Natural and Medical Sciences Institute at the University of TuebingenNMI Natural and Medical Sciences Institute at the University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenNMI Natural and Medical Sciences Institute at the University of TuebingenNMI Natural and Medical Sciences Institute at the University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenDepartment of Neurodegeneration and Hertie-Institute for Clinical Brain Research, Center of Neurology, University of TuebingenAbstract Parkinson’s disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes. Plasminogen activator inhibitor-1 (SERPIN E1) is known for its association with aging processes and exacerbated α-Synuclein pathology. We examined whether SERPIN E1 levels in cerebrospinal fluid (CSF) differ among controls (CON, N = 16) and patients with PD (N = 479) or Dementia with Lewy bodies (DLB, N = 67), considering that these conditions represent a spectrum of α-Synuclein pathology. Kaplan-Meier survival analysis stratified by SERPIN E1 tertile levels was conducted to evaluate phenotype-modifying effects. Elevated levels of SERPIN E1 exhibited an association with increased age and lower MOCA scores. Heightened SERPIN E1 levels were observed in individuals diagnosed with DLB, followed by PD and CON, and in males compared to females. The quantification of SERPIN E1 in CSF could potentially serve as a surrogate marker, depicting (pathological) aging processes.https://doi.org/10.1038/s41531-025-00984-3 |
| spellingShingle | Milan Zimmermann Madeleine Fandrich Meike Jakobi Benjamin Röben Isabel Wurster Stefanie Lerche Claudia Schulte Shahrzad Zimmermann Christian Deuschle Nicole Schneiderhan-Marra Thomas O. Joos Thomas Gasser Kathrin Brockmann Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases npj Parkinson's Disease |
| title | Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases |
| title_full | Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases |
| title_fullStr | Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases |
| title_full_unstemmed | Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases |
| title_short | Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases |
| title_sort | elevated cerebrospinal fluid levels of serpin e1 in participants with lewy body diseases |
| url | https://doi.org/10.1038/s41531-025-00984-3 |
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