Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers
Depression has been shown to be associated with systemic inflammatory activity and the mode of action of several antidepressants appears to involve immunomodulation. Effects on immune system activity have also recently been observed in correlation with therapeutic response to mirtazapine in cardiac...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2013/697872 |
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| author | Shahzad M. Alikhan Jessica A. Lee Luiz Dratcu |
| author_facet | Shahzad M. Alikhan Jessica A. Lee Luiz Dratcu |
| author_sort | Shahzad M. Alikhan |
| collection | DOAJ |
| description | Depression has been shown to be associated with systemic inflammatory activity and the mode of action of several antidepressants appears to involve immunomodulation. Effects on immune system activity have also recently been observed in correlation with therapeutic response to mirtazapine in cardiac patients with depression, but no study has yet examined these effects in otherwise physically healthy depressed patients treated with mirtazapine. This report describes an association between a clinical antidepressant response and a decrease in markers of systemic inflammation observed during pharmacotherapy with mirtazapine in a severely depressed but physically well patient. This observation adds to the evidence that changes in inflammatory responses may be implicated in the mode of action of antidepressants. Further studies of antidepressant responses to mirtazapine and levels of inflammatory markers in depressed patients without medical comorbidity can help elucidate the role of the immune system in the pathophysiology of depression, and hence contribute to the development of novel antidepressant therapies. |
| format | Article |
| id | doaj-art-e87e2bfa611a481e8bf7d1f40a9201d8 |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-e87e2bfa611a481e8bf7d1f40a9201d82025-02-03T01:01:49ZengWileyCase Reports in Psychiatry2090-682X2090-68382013-01-01201310.1155/2013/697872697872Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory MarkersShahzad M. Alikhan0Jessica A. Lee1Luiz Dratcu2ST4 in General Adult Psychiatry, Bracton Centre, Oxleas NHS Foundation Trust, Dartford, Kent DA2 7AF, UKSouth West London and St. George's Mental Health NHS Trust, Springfield University Hospital, 61 Glenburnie Road Tooting, London SW17 7DJ, UKSouth London and Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, London SE5 8AZ, UKDepression has been shown to be associated with systemic inflammatory activity and the mode of action of several antidepressants appears to involve immunomodulation. Effects on immune system activity have also recently been observed in correlation with therapeutic response to mirtazapine in cardiac patients with depression, but no study has yet examined these effects in otherwise physically healthy depressed patients treated with mirtazapine. This report describes an association between a clinical antidepressant response and a decrease in markers of systemic inflammation observed during pharmacotherapy with mirtazapine in a severely depressed but physically well patient. This observation adds to the evidence that changes in inflammatory responses may be implicated in the mode of action of antidepressants. Further studies of antidepressant responses to mirtazapine and levels of inflammatory markers in depressed patients without medical comorbidity can help elucidate the role of the immune system in the pathophysiology of depression, and hence contribute to the development of novel antidepressant therapies.http://dx.doi.org/10.1155/2013/697872 |
| spellingShingle | Shahzad M. Alikhan Jessica A. Lee Luiz Dratcu Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers Case Reports in Psychiatry |
| title | Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers |
| title_full | Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers |
| title_fullStr | Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers |
| title_full_unstemmed | Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers |
| title_short | Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers |
| title_sort | mirtazapine treatment of a severe depressive episode and resolution of elevated inflammatory markers |
| url | http://dx.doi.org/10.1155/2013/697872 |
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