Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand

Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand

Abstract Melioidosis is a life-threatening tropical disease caused by an intracellular gram-negative bacterium Burkholderia pseudomallei. B. pseudomallei polymerizes the host cell actin through autotransporters, BimA, and BimC, to facilitate intracellular motility. Two variations of BimA in B. pseud...

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Main Authors: Charlene Mae Salao Cagape, Rathanin Seng, Natnaree Saiprom, Sarunporn Tandhavanant, Claire Chewapreecha, Usa Boonyuen, T. Eoin West, Narisara Chantratita
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Burkholderia pseudomallei
Melioidosis
BimA
BimC
Actin-based motility
Variation
Online Access:https://doi.org/10.1038/s41598-024-74922-3
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https://doi.org/10.1038/s41598-024-74922-3

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