De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

Abstract Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-human selective tradeoffs by acquiring successive point...

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Main Authors: Alexandra J. Poret, Matthew Schaefers, Christina Merakou, Kathryn E. Mansour, Connor D. Ahern, Georgia K. Lagoudas, Alyssa Haynes, Ashley R. Cross, Joanna B. Goldberg, Roy Kishony, Ahmet Z. Uluer, Alexander J. McAdam, Paul C. Blainey, Sara O. Vargas, Tami D. Lieberman, Gregory P. Priebe
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61168-4
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https://doi.org/10.1038/s41467-025-61168-4

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