Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy

Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy

Abstract Peri-prosthesis osteolysis (PPO) represents the most severe complication of total joint arthroplasty (TJA) surgery and imposes the primary cause of prosthesis failure and subsequent revision surgery. Antiresorptive therapies are usually prescribed to treat PPO, especially for elderly people...

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Bibliographic Details
Main Authors: Xin Liu, Wei Wang, Feng Zhu, Haibo Xu, Gaoran Ge, Xiaolong Liang, Huilin Yang, Yaozeng Xu, Wei Xu, Minggang Wei, Qi Zhou, Dechun Geng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Peri-prosthesis osteolysis
Titanium nanoparticles
Osteoblastogenesis
Ferroptosis
GPX4
Urolithin A
Online Access:https://doi.org/10.1186/s12951-024-03049-4
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https://doi.org/10.1186/s12951-024-03049-4

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