A robust method for assessing mitochondrial function in healthy and diseased frozen cardiac tissue

A robust method for assessing mitochondrial function in healthy and diseased frozen cardiac tissue

Abstract Cardiovascular diseases are often associated with impairment in mitochondrial function. However, existing respirometry measuring mitochondrial function are limited by the necessity of fresh tissue samples. This study develops a method with tailored substrate-inhibitor titration (TSIT) of mi...

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Main Authors: Liangyu Hu, Alexia van Rinsum, Rocco Caliandro, Xi Qi, Shuxiu Fan, Xinyi Jiang, Jur Massop, Melissa Bekkenkamp-Grovenstein, Christiane Ott, Tilman Grune, Melissa A. E. van de Wal, Werner J. H. Koopman, Marcel Giesbers, Monika Gladka, Jaap Keijer, Deli Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08608-5
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https://doi.org/10.1038/s42003-025-08608-5

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