Polyomavirus large T antigens: Unraveling a complex interactome

Polyomavirus large T antigens: Unraveling a complex interactome

All members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA replication, regulation of viral gene expression, and the manipulation of numerous cellular pathways. Over 100 polyomaviruses have been discovered in hosts ranging from arthropods and...

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Bibliographic Details
Main Authors: Matthew R. Googins, Ping An, Christian H. Gauthier, James M. Pipas
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Tumour Virus Research
Subjects:
Polyomaviruses
Large T antigen
Protein-protein interactions
Phosphorylation
DNA replication
Online Access:http://www.sciencedirect.com/science/article/pii/S2666679024000302
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