In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles

The 5′ untranslated region (5′ UTR) of rodent hepacivirus (RHV) and pegivirus (RPgV) contains sequence homology to the HCV type III internal ribosome entry sites (IRES). Utilizing a monocistronic expression vector with an RNA polymerase I promoter to drive transcription, we show cell-specific IRES t...

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Bibliographic Details
Main Authors: Stuart Sims, Kevin Michaelsen, Sara Burkhard, Cornel Fraefel
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Advances in Virology
Online Access:http://dx.doi.org/10.1155/2021/5569844
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