Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells
Liver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs). Previously, we reported that hypoxia‐inducible factor‐1 (Hif‐1) regulates activation of HSCs through autophagy. In current work, human HSC cell l...
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| Format: | Article |
| Language: | English |
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Wiley
2018-03-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.12379 |
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| _version_ | 1846108036754571264 |
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| author | Fei Hong Lu Wan Jie Liu Ke Huang Zhenmeng Xiao Yingjing Zhang Chunwei Shi |
| author_facet | Fei Hong Lu Wan Jie Liu Ke Huang Zhenmeng Xiao Yingjing Zhang Chunwei Shi |
| author_sort | Fei Hong |
| collection | DOAJ |
| description | Liver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs). Previously, we reported that hypoxia‐inducible factor‐1 (Hif‐1) regulates activation of HSCs through autophagy. In current work, human HSC cell line LX‐2 was used as cell model. It was determined that trimethylation of H3 histone on lysine 4 (H3K4me3) occurred in the Hif‐1 transcriptional complex. Inhibition of modifications of histone methylation suppressed Hif‐1 nuclear transport, autophagosome formation, and activation of LX‐2 cells. These data suggest that histone methylation modification plays an important role in the Hif‐1 signaling cascade regulating HSC activation. |
| format | Article |
| id | doaj-art-e7e96c7a19ba411eb7d3da97c4673f96 |
| institution | Kabale University |
| issn | 2211-5463 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj-art-e7e96c7a19ba411eb7d3da97c4673f962024-12-26T06:31:12ZengWileyFEBS Open Bio2211-54632018-03-018340641510.1002/2211-5463.12379Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cellsFei Hong0Lu Wan1Jie Liu2Ke Huang3Zhenmeng Xiao4Yingjing Zhang5Chunwei Shi6Department of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathogen Biology School of Basic Medicine Huazhong University of Science and Technology Wuhan ChinaLiver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs). Previously, we reported that hypoxia‐inducible factor‐1 (Hif‐1) regulates activation of HSCs through autophagy. In current work, human HSC cell line LX‐2 was used as cell model. It was determined that trimethylation of H3 histone on lysine 4 (H3K4me3) occurred in the Hif‐1 transcriptional complex. Inhibition of modifications of histone methylation suppressed Hif‐1 nuclear transport, autophagosome formation, and activation of LX‐2 cells. These data suggest that histone methylation modification plays an important role in the Hif‐1 signaling cascade regulating HSC activation.https://doi.org/10.1002/2211-5463.12379hepatic stellate cellsHif‐1histone methylation |
| spellingShingle | Fei Hong Lu Wan Jie Liu Ke Huang Zhenmeng Xiao Yingjing Zhang Chunwei Shi Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells FEBS Open Bio hepatic stellate cells Hif‐1 histone methylation |
| title | Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells |
| title_full | Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells |
| title_fullStr | Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells |
| title_full_unstemmed | Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells |
| title_short | Histone methylation regulates Hif‐1 signaling cascade in activation of hepatic stellate cells |
| title_sort | histone methylation regulates hif 1 signaling cascade in activation of hepatic stellate cells |
| topic | hepatic stellate cells Hif‐1 histone methylation |
| url | https://doi.org/10.1002/2211-5463.12379 |
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