Chronic Treatment with a Promnesiant GABA-A 𝜶𝟓-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

Chronic Treatment with a Promnesiant GABA-A 𝜶𝟓-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors (α5IA) have promnesiant activity. Interestingly, we have recently shown that α5IA can rescue cognitive deficits in Ts65Dn mice, a Down syndrome...

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Main Authors: J. Braudeau, L. Dauphinot, A. Duchon, A. Loistron, R. H. Dodd, Y. Hérault, B. Delatour, M. C. Potier
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Advances in Pharmacological Sciences
Online Access:http://dx.doi.org/10.1155/2011/153218
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http://dx.doi.org/10.1155/2011/153218

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