Nitrous oxide exerts rewarding effect via regulating D1 receptor and BDNF pathway in ventral tegmental area-nucleus accumbens dopamine circuit

Abstract Recreational use of nitrous oxide (N2O) has risen dramatically over the past decades. This study aimed to examine its rewarding effect and the underlying mechanisms. The exposure of mice to a subanesthetic concentration (20%) of N2O for 30 min for 4 consecutive days paired with N2O in the m...

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Bibliographic Details
Main Authors: Wen-Qi Li, Sheng-Nan Liu, Si-Chang Yang, Xiang Lin, Zhang-Jin Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03257-y
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