Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea

Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea

IntroductionThe trachea is essential for proper airflow to the lungs for gas exchange. Frequent congenital tracheal malformations affect the cartilage, causing the collapse of the central airway during the respiratory cycle. We have shown that Notum, a Wnt ligand de-acylase that attenuates the canon...

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Bibliographic Details
Main Authors: Natalia Bottasso-Arias, Megha Mohanakrishnan, Sarah Trovillion, Kaulini Burra, Nicholas X. Russell, Yixin Wu, Yan Xu, Debora Sinner
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Wnt
Notum
cartilage
morphogenesis
patterning
respiratory tract
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1523833/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1523833/full

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