SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant

IntroductionAbnormal intracellular accumulation of Tau aggregates is a hallmark of Alzheimer’s disease (AD) and other Tauopathies, such as Frontotemporal dementia (FTD). Tau deposits primarily affect neurons, but evidence indicates that glial cells may also be affected and contribute distinctively t...

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Bibliographic Details
Main Authors: Franca Orsini, Rosaria Pascente, Annacarla Martucci, Sara Palacino, Paul Fraser, Ottavio Arancio, Luana Fioriti
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cellular Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1437995/full
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