Immunogenicity and protective efficacy of DHBV DNA vaccines expressing envelope and capsid fusion proteins in ducks delivered by attenuated Salmonella typhimurium

Immunogenicity and protective efficacy of DHBV DNA vaccines expressing envelope and capsid fusion proteins in ducks delivered by attenuated Salmonella typhimurium

Duck hepatitis B virus (DHBV) shares many basic characteristics with hepatitis B virus (HBV) and is an attractive model for vaccine development. In this study, DHBV DNA vaccines were designed to express envelope and capsid fusion proteins to enhance the breadth of immune response in ducks. Attenuate...

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Bibliographic Details
Main Authors: Si-yang LIU, Ren-yong JIA, Qing-qing LI, Dai-shen FENG, Hao-yue SHEN, Cui YANG, Ming-shu WANG, De-kang ZHU, Shun CHEN, Ma-feng LIU, Xin-xin ZHAO, Zhong-qiong YIN, Bo JING, An-chun CHENG
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-04-01
Series:Journal of Integrative Agriculture
Subjects:
fusion DNA genes
attenuated Salmonella typhimurium (SL7207)
hepatitis B virus (HBV)
duck hepatitis B virus (DHBV)
oral immunization
Online Access:http://www.sciencedirect.com/science/article/pii/S209531191761829X
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