A Pangenomic Approach to Improve Population Genetics Analysis and Reference Bias in Underrepresented Middle Eastern and Horn of Africa Populations

A Pangenomic Approach to Improve Population Genetics Analysis and Reference Bias in Underrepresented Middle Eastern and Horn of Africa Populations

Genomics plays a crucial role in addressing health disparities, yet most studies rely on the hg38 linear reference genome, limiting the potential of pangenomic approaches, particularly for underrepresented populations. In this study, we focus on characterising East African populations, particularly...

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Bibliographic Details
Main Authors: Adrien Oliva, Rachel Foare, Peter Campbell, Natalie A. Twine, Denis C. Bauer, Angad Singh Johar
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomolecules
Subjects:
pangenomics
variation graph
reference bias
genomic medicine
population genetics
underrepresented populations
Online Access:https://www.mdpi.com/2218-273X/15/4/582
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