A Gallbladder‐Specific Hydrophobic Bile Acid‐FXR‐MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation

A Gallbladder‐Specific Hydrophobic Bile Acid‐FXR‐MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation

Abstract Differences in the distribution of hydrophilic and hydrophobic bile acids (BA) are observed in mouse models of non‐alcoholic fatty liver disease (NAFLD) induced by a high‐fat‐cholesterol “Western‐style” diet (WD), and cholesterol gallstone disease (CGD) induced by a lithogenic diet. Despite...

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Bibliographic Details
Main Authors: Hongtan Chen, Xin Jiang, Yiqiao Li, Honggang Guo, Jianguo Wu, Sha Li, Fengling Hu, Guoqiang Xu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
caveolae
cholesterol gallstone
farnesoid X receptor
hydrophobic bile acid pool
protein kinase Cζ
Online Access:https://doi.org/10.1002/advs.202401956
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https://doi.org/10.1002/advs.202401956

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