Interfacial Morphodynamics of Proliferating Microbial Communities
In microbial communities, various cell types often coexist by occupying distinct spatial domains. What determines the shape of the interface between such domains—which, in turn, influences the interactions between cells and overall community function? Here, we address this question by developing a c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Physical Society
2025-01-01
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| Series: | Physical Review X |
| Online Access: | http://doi.org/10.1103/PhysRevX.15.011016 |
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| _version_ | 1832582551979425792 |
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| author | Alejandro Martínez-Calvo Carolina Trenado-Yuste Hyunseok Lee Jeff Gore Ned S. Wingreen Sujit S. Datta |
| author_facet | Alejandro Martínez-Calvo Carolina Trenado-Yuste Hyunseok Lee Jeff Gore Ned S. Wingreen Sujit S. Datta |
| author_sort | Alejandro Martínez-Calvo |
| collection | DOAJ |
| description | In microbial communities, various cell types often coexist by occupying distinct spatial domains. What determines the shape of the interface between such domains—which, in turn, influences the interactions between cells and overall community function? Here, we address this question by developing a continuum model of a 2D spatially structured microbial community with two distinct cell types. We find that, depending on the balance of the different cell proliferation rates and substrate friction coefficients, the interface between domains is either stable and smooth or unstable and develops fingerlike protrusions. We establish quantitative principles describing when these different interfacial behaviors arise and find good agreement with both the results of previous experimental reports as well as new experiments performed here. Our work, thus, helps to provide a biophysical basis for understanding the interfacial morphodynamics of proliferating microbial communities as well as a broader range of proliferating active systems. |
| format | Article |
| id | doaj-art-e6ceb0acc5c345df82bec9d38aa6d951 |
| institution | Kabale University |
| issn | 2160-3308 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review X |
| spelling | doaj-art-e6ceb0acc5c345df82bec9d38aa6d9512025-01-29T16:52:29ZengAmerican Physical SocietyPhysical Review X2160-33082025-01-0115101101610.1103/PhysRevX.15.011016Interfacial Morphodynamics of Proliferating Microbial CommunitiesAlejandro Martínez-CalvoCarolina Trenado-YusteHyunseok LeeJeff GoreNed S. WingreenSujit S. DattaIn microbial communities, various cell types often coexist by occupying distinct spatial domains. What determines the shape of the interface between such domains—which, in turn, influences the interactions between cells and overall community function? Here, we address this question by developing a continuum model of a 2D spatially structured microbial community with two distinct cell types. We find that, depending on the balance of the different cell proliferation rates and substrate friction coefficients, the interface between domains is either stable and smooth or unstable and develops fingerlike protrusions. We establish quantitative principles describing when these different interfacial behaviors arise and find good agreement with both the results of previous experimental reports as well as new experiments performed here. Our work, thus, helps to provide a biophysical basis for understanding the interfacial morphodynamics of proliferating microbial communities as well as a broader range of proliferating active systems.http://doi.org/10.1103/PhysRevX.15.011016 |
| spellingShingle | Alejandro Martínez-Calvo Carolina Trenado-Yuste Hyunseok Lee Jeff Gore Ned S. Wingreen Sujit S. Datta Interfacial Morphodynamics of Proliferating Microbial Communities Physical Review X |
| title | Interfacial Morphodynamics of Proliferating Microbial Communities |
| title_full | Interfacial Morphodynamics of Proliferating Microbial Communities |
| title_fullStr | Interfacial Morphodynamics of Proliferating Microbial Communities |
| title_full_unstemmed | Interfacial Morphodynamics of Proliferating Microbial Communities |
| title_short | Interfacial Morphodynamics of Proliferating Microbial Communities |
| title_sort | interfacial morphodynamics of proliferating microbial communities |
| url | http://doi.org/10.1103/PhysRevX.15.011016 |
| work_keys_str_mv | AT alejandromartinezcalvo interfacialmorphodynamicsofproliferatingmicrobialcommunities AT carolinatrenadoyuste interfacialmorphodynamicsofproliferatingmicrobialcommunities AT hyunseoklee interfacialmorphodynamicsofproliferatingmicrobialcommunities AT jeffgore interfacialmorphodynamicsofproliferatingmicrobialcommunities AT nedswingreen interfacialmorphodynamicsofproliferatingmicrobialcommunities AT sujitsdatta interfacialmorphodynamicsofproliferatingmicrobialcommunities |