Antitumor effect of the curaxin CBL0137 on the models of colon cancer

Antitumor effect of the curaxin CBL0137 on the models of colon cancer

Curaxins represent low molecular weight carbazole derivatives, which simultaneously activate p53-dependent apoptosis and inhibit NF-kBdependent signal transduction pathways. Antitumor activity of curaxin CBL0137 was demonstrated in vivo on the model of solid transplantable mouse colon adenocarcinoma...

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Main Authors: T. I. Fetisov, L. R. Tilova, E. A. Lesovaya, E. E. Antoshina, T. G. Gor’kova, L. S. Trukhanova, O. V. Morozova, E. V. Shipaeva, R. V. Ivanov, A. A. Purmal, G. A. Belitskiy, M. G. Yakubovskaya, A. V. Gudkov, K. V. Gurova, K. I. Kirsanov
Format: Article
Language:Russian
Published: ABV-press 2016-09-01
Series:Успехи молекулярной онкологии
Subjects:
colon adenocarcinoma
transplantable tumor
akatol
curaxin
cbl0137
nf-kb-signal transduction pathway
cox2
Online Access:https://umo.abvpress.ru/jour/article/view/71
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