Omega-3 attenuates the severity of medication-related osteonecrosis of the jaws in rats treated with zoledronate.

Omega-3 attenuates the severity of medication-related osteonecrosis of the jaws in rats treated with zoledronate.

This study aimed to evaluate the ability of ω-3 to modulate the tissue response in rats with MRONJ, focusing on histopathological and immunohistochemical parameters. Forty Wistar rats were subjected to bilateral ovariectomy and, three months later, the medication regimen with ZOL (100μg/kg; groups Z...

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Main Authors: Juliano Milanezi de Almeida, Halef Diego Turini, Henrique Rinaldi Matheus, Otávio Augusto Pacheco Vitória, Bianca Rafaeli Piovezan, Ruan Henrique Barra Dalmonica, Elisa Mara de Abreu Furquim, Edilson Ervolino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0320413
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https://doi.org/10.1371/journal.pone.0320413

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