High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

Abstract Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a frequently encountered disorder characterized by voiding symptoms and pelvic or perineal pain. Proinflammatory T helper 17 (Th17) cells are essential for triggering the development of CP/CPPS. High-salt diet (HSD) co...

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Main Authors: Jing Chen, Rui Feng, Bin-Bin Gong, Wei-Kang Wu, Bang-Shun Dai, Rui Tan, Wen-Long Xu, Tong Meng, Xiao-Bin Wang, Yun-Zheng Xiao, Cheng Yang, Li Zhang, Chao-Zhao Liang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Military Medical Research
Subjects:
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)
High-salt diet
5-Hydroxyindole acetic acid (5HIAA)
Serum and glucocorticoid-regulated kinase 1 (SGK1)
Th17 cells
Online Access:https://doi.org/10.1186/s40779-025-00607-1
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https://doi.org/10.1186/s40779-025-00607-1

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