Effect of Hypoxia on Siglec-7 and Siglec-9 Receptors and Sialoglycan Ligands and Impact of Their Targeting on NK Cell Cytotoxicity

Effect of Hypoxia on Siglec-7 and Siglec-9 Receptors and Sialoglycan Ligands and Impact of Their Targeting on NK Cell Cytotoxicity

Background/Objectives: Tumor microenvironmental hypoxia is an established hallmark of solid tumors. It significantly contributes to tumor aggressiveness and therapy resistance and has been reported to affect the balance of activating/inhibitory surface receptors’ expression and activity on NK cells....

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Bibliographic Details
Main Authors: Husam Nawafleh, Nagwa Zeinelabdin, Michelle K. Greene, Anitha Krishnan, Linus Ho, Mohamed Genead, Derek Kunimoto, Christopher J. Scott, Michael Tolentino, Salem Chouaib
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceuticals
Subjects:
siglec receptors
sialoglycan ligands
hypoxia
NK cells
nanoparticles
immune synapses
Online Access:https://www.mdpi.com/1424-8247/17/11/1443
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