Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production

Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production

BackgroundPathogens trigger metabolic reprogramming, leading to the formation of foamy macrophages (FMs). This process provides a favorable environment for bacterial proliferation and enables bacteria to evade immune killing.ObjectiveTo elucidate the mechanisms by which pathogens escape immune surve...

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Bibliographic Details
Main Authors: Chuan Wang, Yuan Zhang, Tingting Liu, Zihao Mi, Peidian Shi, Zhenzhen Wang, Wenchao Li, Honglei Wang, Hong Liu, Furen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
foamy macrophage
mycobacterial infection
CXCL13
antimicrobial proteins
NLRP12
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541954/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541954/full

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