Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice

Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice

Abstract Background Osteoarthritis (OA) is a degenerative disease characterized by subchondral bone sclerosis, chronic inflammation, and cartilage degradation. Abnormal mechanical stress by meniscal deviation activates osteoclasts and induces the release of transforming growth factor-beta (TGF-β), w...

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Main Authors: Yuji Fukuda, Munehisa Shimamura, Yuki Etani, Takaaki Noguchi, Takuya Kurihara, Atsushi Goshima, Taihei Miura, Makoto Hirao, Nagahiro Ochiai, Nan Ju, Atsushi Sugimoto, Takashi Kanamoto, Ken Nakata, Seiji Okada, Kosuke Ebina
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Destabilization of the medial meniscus
Macrophage
Microglia healing peptide 1 with N-terminal acetylation and C-terminal amidation
Osteoarthritis
Osteoclast
Receptor activator of nuclear factor-kappa B ligand
Online Access:https://doi.org/10.1186/s13075-025-03609-5
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https://doi.org/10.1186/s13075-025-03609-5

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