Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors

Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors

Abstract α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target in the treatment of type 2 diabetes mellitus. Present work introduces1,2,4triazolo[1,5-a]pyridine as a novel, potent scaffold for α-glucosidase inhibition. A diverse scope of targeted compou...

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Main Authors: Fariba Peytam, Parham Foroumadi, Hayrettin Ozan Gulcan, Maryam Norouzbahari, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fahimeh Ghasemi, Mohammadreza Torabi, Behnaz Bameri, Maliheh Barazandeh Tehrani, Loghman Firoozpour, Alireza Foroumadi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
[1,2,4]Triazolo[1,5-a]pyridine
α-Glucosidase
α-Amylase
Machine learning model
Online Access:https://doi.org/10.1038/s41598-025-01819-0
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https://doi.org/10.1038/s41598-025-01819-0

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