Fused oxazepine-naphthoquinones as novel cytotoxic agents with diverse modes of action in yeast

The naphthoquinone moiety is commonly found in numerous natural cytotoxic compounds with diverse and pleiotropic modes of action (MOAs). The moiety can exist as a standalone pharmacophore or combined with other pharmacophores to enrich their MOAs. Here, we report that the synthetic fusion of naphtho...

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Bibliographic Details
Main Authors: Laura Anaissi-Afonso, Silvia Santana-Sosa, Isabel Lorenzo-Castrillejo, Grant McNaughton-Smith, Félix Machín
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
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Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024171368
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