Biomimetic siRNA-METTL3 loading nanosystem alleviates myocardial hypertrophy by regulating the FASN and SCD1 m6A modification

Biomimetic siRNA-METTL3 loading nanosystem alleviates myocardial hypertrophy by regulating the FASN and SCD1 m6A modification

RNA m6A modification plays a vital role in regulating cardiac function; however, its comprehensive mechanisms require further exploration. We observed that the expression of METTL3, a m6A methyltransferase, is significantly increased in hypertrophic hearts as well as during phenylephrine (PE)-induce...

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Main Authors: Peng Teng, Xiaoyi Dai, Yuefeng Wu, Yingying Wang, Zhen Jia, Chenqiu Wang, Shixing Wang, Runhua Li, Qi Zheng, Yiming Ni, Wei Jiang, Liguo Jian, Datun Qi, Dongdong Jian, Liang Ma
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials & Design
Subjects:
Cardiac hypertrophy
METTL3
Platelet liposome fusion membrane
RNA modification
FASN
SCD1
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525007087
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