Phosphorylation of nucleosides by P-N bond species generated from prebiotic reduced phosphorus sources

Abstract P-N species e.g., amidophosphates readily phosphorylate organics, thereby overcoming the so-called ‘Phosphate Problem’. However, the formation of amidophosphates by plausible early Earth geochemical pathways is limited. We herein show that ammonolysis of the prebiotically plausible dimer of...

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Bibliographic Details
Main Authors: Maheen Gull, Harold A. Cruz, Ramanarayanan Krishnamurthy, Matthew A. Pasek
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01577-0
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