Polygenic risk scores of rheumatoid arthritis associated with seropositivity and bone erosions in a Taiwanese population

Polygenic risk scores of rheumatoid arthritis associated with seropositivity and bone erosions in a Taiwanese population

Abstract Polygenic risk scores (PRS) are widely used to estimate disease risks and predict clinical outcomes. However, ethnic differences exist worldwide. We aimed to use PRS for predicting the development of rheumatoid arthritis (RA) in a Taiwanese population and investigate whether PRS of RA may b...

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Main Authors: Ting-Shuan Wu, Yen-Ju Chen, Chia-Ni Hsiung, Chien-Lin Mao, Chia-Yi Wei, I-Chieh Chen, Chung-Mao Kao, Tzu-Hung Hsiao, Wen-Nan Huang, Yi-Hsing Chen, Yi-Ming Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
PRS
RA
Seropositivity
Rheumatoid factor
Anti-citrullinated protein antibody
Bone erosion
Online Access:https://doi.org/10.1038/s41598-025-08254-1
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https://doi.org/10.1038/s41598-025-08254-1

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