Distinct metabolome and flux responses in the retinal pigment epithelium to cytokines associated with age-related macular degeneration: comparison of ARPE-19 cells and eyecups

Distinct metabolome and flux responses in the retinal pigment epithelium to cytokines associated with age-related macular degeneration: comparison of ARPE-19 cells and eyecups

Abstract Age-related macular degeneration (AMD) is associated with chronic inflammation of the retinal pigment epithelium (RPE) and elevated cytokines including TNFα, TGF-β, IL-6, and IL-1β. As a metabolic intermediary supporting aerobic glycolysis in the adjacent photoreceptors, the RPE’s metabolic...

Full description

Saved in:
Bibliographic Details
Main Authors: David S. Hansman, Kelly Lim, Daniel Thomas, Robert J. Casson, Daniel J. Peet
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Age-related macular degeneration
Retinal pigment epithelium
Metabolism
Retina inflammation
Cytokines
Metabolic ecosystem
Online Access:https://doi.org/10.1038/s41598-025-93882-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-93882-w

Similar Items