Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age

Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age

Estimation of chronological age is particularly informative in forensic contexts. Assessment of DNA methylation status allows for the prediction of age, though the accuracy may vary across models. In this study, we started with a carefully designed discovery cohort with more elderly subjects than ot...

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Main Authors: Bowen Zhu, Dean Li, Guojing Han, Xue Yao, Hongqin Gu, Tao Liu, Linghua Liu, Jie Dai, Isabella Zhaotong Liu, Yanlin Liang, Jian Zheng, Zheming Sun, He Lin, Nan Liu, Haidong Yu, Meifang Shi, Gaofang Shen, Zhaohui Hu, Lefeng Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging
Subjects:
DNA methylation
age-prediction model
multiplexing
massive parallel sequencing
targeted region
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2025.1467639/full
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https://www.frontiersin.org/articles/10.3389/fragi.2025.1467639/full

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