MiR-204 regulates autophagy and cell viability by targeting BDNF and inhibiting the NTRK2-dependent PI3K/Akt/mTOR pathway in a human granulosa cell line exposed to bisphenol A

MiR-204 regulates autophagy and cell viability by targeting BDNF and inhibiting the NTRK2-dependent PI3K/Akt/mTOR pathway in a human granulosa cell line exposed to bisphenol A

Bisphenol A (BPA) is a widespread endocrine disruptor that mimics estrogen. The accumulation of BPA within the human body has been shown to be detrimental to ovarian function. However, few studies have focused on the specific mechanisms by which it causes harm to granulosa cells (GCs), pivotal ovari...

Full description

Saved in:
Bibliographic Details
Main Authors: Chunming Li, Zhenyan Cui, Zekun Liu, Huiyu Fan, Yibing Lan, Jie Luo, Fei Ruan, Yizhou Huang, Ketan Chu, Yihua Wu, Dajing Xia, Jianhong Zhou
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ovarian granulosa cell
MiR-204
BDNF/NTRK2
PI3K/Akt/mTOR signaling
Bisphenol A
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324013800
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0147651324013800

Similar Items