Synthesis and Molecular Modeling of Antioxidant and Anti-Inflammatory Five-Membered Heterocycle–Cinnamic Acid Hybrids

Synthesis and Molecular Modeling of Antioxidant and Anti-Inflammatory Five-Membered Heterocycle–Cinnamic Acid Hybrids

In this study, the design and synthesis of a novel series of cinnamic acid and 1,2,4-triazole hybrids were reported, aiming to enhance antioxidant and lipoxygenase inhibitory activities through pharmacophore combination. Cinnamic acid derivatives and 1,2,4-triazoles exhibit a broad spectrum of biolo...

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Bibliographic Details
Main Authors: Konstantinos Theodoridis, Eleftherios Charissopoulos, Dimitra Tsioumela, Eleni Pontiki
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
cinnamic acid derivatives
1,2,4-triazole
1,3,4-oxadiazole
chimeric molecules
anti-inflammatory
antioxidant
Online Access:https://www.mdpi.com/1420-3049/30/15/3148
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https://www.mdpi.com/1420-3049/30/15/3148

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