Exploring the potential of selective FKBP51 inhibitors on melanoma: an investigation of their in vitro and in vivo effects

Exploring the potential of selective FKBP51 inhibitors on melanoma: an investigation of their in vitro and in vivo effects

Abstract FKBP51 is a marker of melanocyte malignancy, correlating with vertical growth phase and lesion thickness. It promotes the typical features of epithelial to mesenchymal transition and sustains apoptosis resistance. The present study aimed to assess in vitro and in vivo the efficacy against m...

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Main Authors: Laura Marrone, Valeria Di Giacomo, Chiara Malasomma, Marialuisa Alessandra Vecchione, Felix Hausch, Massimiliano Cacace, Lucia D’Esposito, Martina Tufano, Paolo D’Arrigo, Maria Fiammetta Romano, Simona Romano
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02430-y
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https://doi.org/10.1038/s41420-025-02430-y

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